Producción Científica

Proyectos

2024-2028. “Integrated Process of Dialysis and Reactive Purification of Succinic Acid to Diethyl Succinate via Enzymatic Esterification in a HBA Anion Based Ionic Liquid Medium” FONDECYT REGULAR N° 1241812. Investigador Principal

2024-2028. ” In-situ product removal of aromas produced by fermentation: solvent selection and solute purification” FONDECYT REGULAR N° 1240931. Co Investigador

2023-2025. “Desarrollo de un prototipo avanzado de producción de gas licuado a través de la optimización de un proceso termoquímico utilizando aceites residuales de fritura” FONDEF IT 315454. Director Alterno

2023-2024 “Evaluación de la actividad Antioxidante y la estabilidad del Hidroxitirosol en un solvente eutéctico profundo natural como base de un nutraceútico comercial” Ci2030 UCSC. Investigador Principal.

2023-2026 “Design of tissue engineering scaffolds with drug delivery capability from 3d printing of nanocomposites and a single-step supercritical impregnation/ foaming proces” FONDECYT REGULAR N° 1230795. Coinvestigador.

2019-2023. “Improvement of biotechnological synthesis of succinic acid from glycerol using gelled ionic liquid membranes”. FONDECYT de Iniciación en Investigación N°11190679. Investigador Principal

2020-2023. “Desarrollo y validación de metodologías para la obtención de un concentrado de proteínas vegetales a partir de subproductos agroindustriales de la Región del Maule: Estrategias para la producción de nuevos productos para consumo humano”. Programa provisión FIC Regional año 2020. Código BIP N° 40.027.613-0. Investigador

2018-2019. “Experimental and theoretical characterization of butanol transfer through asymmetric pervaporation membranes based on gelled task-specific ionic liquids”. Proyecto Dicyt 021811RF. Investigador Postdoctorado.

2017-2018. “Obtention of hydroxytyrosol from agricultural wastes using deep eutectic solvents (DES) and supercritical CO2 as re-extraction phase” FONDECYT N°11150255. Asistente investigación

2013-2016. “Development of asymmetric ionic liquid-based membranes for pervaporation of biobutanol”, FONDECYT N° 1140208. Tesis Doctoral.

2011-2013. “Supercritical fluid extraction of organic compounds from aqueous solutions using gelled ionic liquid membranes”, FONDECYT N °1100305. Tesis Magister.

Artículos científicos

Todas las publicaciones están indexadas en WoS (Core Collection: Science Citation Index Expanded), salvo que se indique otra indexación.

Castro-Muñoz, R. Cabezas, M. Plata-Gryl (2024) Mangiferin: A comprehensive review on its extraction, purification and uses in food systems. Advances in Colloid and Interface Science. 103188. https://doi.org/10.1016/j.cis.2024.103188

F. Olea, H. Estay, PP. Jofré-Ulloa, R. Cabezas, G. Merlet, A. Araya, J. Romero (2024) “A review towards selective cobalt recovery in solvent extraction: Potential of ionic liquids as diluents and extractants”. Separation and Purification Technology, 127758. https://doi.org/10.1016/j.seppur.2024.127758

T. González, R. Castro-Muñoz, M. Vera, G. Merlet, L. Pino-Soto, R. Cabezas (2024) “Polyether-block-amide PEBA membranes for gas separation and pervaporation; Current Design and applications”. Journal of Industrial and Engineering Chemistry. https://doi.org/10.1016/j.jiec.2024.02.002

Cabezas R, González-Revuelta D, Zurob E, Olea F, Quijada-Maldonado E, Gorri D (2024) PEBAX polymer inclusion hydrophobic deep eutectic solvent membranes for pervaporation of biobutanol: Mass transfer and COSMO-RS analysis. Journal of Molecular Liquids 395: 123909. DOI: 10.1016/j.molliq.2023.123909.

Castro-Muñoz R, Boczkaj G, Cabezas R (2023) A perspective on missing aspects in ongoing purification research towards Melissa officinalis. Foods 12(9): 1916. DOI: 10.3390/foods12091916.

Merlet G, Becerra J, Zurob E, Plaza A, Romero J, Quijada-Maldonado E, Pino-Soto L, Cabezas R (2023) In-situ recovery of butanol from ABE fermentation solution by hydrophobic ionic liquid perstraction in tubular membranes assisted with vacuum. Separation and Purification Technology 314: 123630. DOI: 10.1016/j.seppur.2023.123630.

Olea F, Valenzuela M, Zurob E, Parraguez B, Abejón R, Cabezas R, Merlet G, Tapia R, Romero J, Quijada-Maldonado E (2023) Hydrophobic eutectic solvents for the selective solvent extraction of molybdenum (VI) and rhenium (VII) from a synthetic pregnant leach solution. Journal of Molecular Liquids 385: 122415. DOI: 10.1016/j.molliq.2023.122415.

Plaza A, Rodríguez L, Concha-Meyer AA, Cabezas R, Zurob E, Merlet G, Palomo I, Fuentes E (2023) Effects of extraction methods on phenolic content, antioxidant and antiplatelet activities of tomato pomace extracts. Plants 12(5): 1188. DOI: 10.3390/plants12051188.

Rivera P, Villegas C, Cabezas R, Pérez B, Torres A, de Dicastillo CL, Garrido L, Galvez P, Araya C, Romero J (2023) Development of PLA suture materials by extrusion, electrospinning and supercritical CO2 impregnation of ibuprofen and naproxen. The Journal of Supercritical Fluids 194: 105854. DOI: 10.1016/j.supflu.2023.105854.

Araya-López C, Carrera P, Torres A, Pino-Soto L, Quijada-Maldonado E, Merlet G, Romero J, Plaza A, Cabezas R (2022a) Analysis of microwave-assisted heating and water extraction from imidazolium and phosphonium based ionic liquids. Thermochimica Acta 714: 179262. DOI: 10.1016/j.tca.2022.179262.

Araya-López C, Contreras J, Merlet G, Cabezas R, Olea F, Villarroel E, Salazar R, Romero J, Quijada-Maldonado E (2022b) [Tf2N]-based ionic liquids for the selective liquid-liquid extraction of levulinic acid/formic acid: COSMO-RS screening and ternary LLE experimental data. Fluid Phase Equilibria 561: 113518. DOI: 10.1016/j.fluid.2022.113518.

Araya‐López C, Conejeros J, Valdebenito C, Cabezas R, Merlet G, Marco JF, Abarca G, Salazar R, Romero J (2022c) Triazolium‐based ionic liquids supported on alumina as catalysts to produce 5‐HMF from fructose. ChemCatChem 14(11): e202200046. DOI: 10.1002/cctc.202200046.

Cabezas RA, Riquelme CA, Merlet G, Quijada-Maldonado E, Romero JR (2022a) Separation of biobutanol from fermentation solutions by perstraction using [P6,6,6,14][Tf2N] as receiving phase: phase temperature analysis. Chemical Engineering Transactions 96: 265-270. DOI: 10.3303/CET2296045.

Cabezas R, Zurob E, Gomez B, Merlet G, Plaza A, Araya-Lopez C, Romero J, Olea F, Quijada-Maldonado E, Pino-Soto L, Gonzalez T, Castro-Muñoz R (2022) Challenges and possibilities of deep eutectic solvent-based membranes. Industrial & Engineering Chemistry Research 61(48): 17397-17422. DOI: 10.1021/acs.iecr.2c02747.

Castro-Muñoz R, Gontarek-Castro E, Karczewski J, Cabezas R, Merlet G, Araya-Lopez C, Boczkaj G (2022) Hybrid cross-linked chitosan/protonated-proline:glucose DES membranes with superior pervaporation performance for ethanol dehydration. Journal of Molecular Liquids 360: 119499. DOI: 10.1016/j.molliq.2022.119499.

Merlet G, Flores M, Villarroel E, Araya-López C, Cabezas R, Pino-Soto L, Romero J, Quijada-Maldonado E (2022) Design of a perstraction-based extraction system for the removal of polychlorinated biphenyls from bovine milk via COSMO-RS: membrane screening. Separation and Purification Technology 290: 120879. DOI: 10.1016/j.seppur.2022.120879.

Olea F, Durán G, Díaz G, Villarroel E, Araya-López C, Cabezas R, Merlet G, Romero J, Quijada-Maldonado E (2022) Ionic liquids for the selective solvent extraction of lithium from aqueous solutions: a theoretical selection using COSMO-RS. Minerals 12(2): 190. DOI: 10.3390/min12020190.

Quijada‐Maldonado E, Román R, Merlet G, Pérez B, Cabezas R, Tapia R, Olea F, Villarroel E, Araya‐López C, Romero J (2022) Rhenium(VII) extraction from sulfuric aqueous solutions using ionic liquids as diluent and extractant: insights on the extraction stoichiometry and process parameters. Journal of Chemical Technology and Biotechnology 97(5): 1224-1233. DOI: 10.1002/jctb.7013.

Villarroel E, Olea F, Araya-López C, Merlet G, Cabezas R, Romero J, Quijada-Maldonado E (2022a) COSMO-RS evaluation as a tool for prediction of solvents in dispersive liquid-phase microextraction: evaluation of conventional solvents and ionic liquids as extractants. Journal of Molecular Liquids 354: 118861. DOI: 10.1016/j.molliq.2022.118861.

Villarroel E, Olea F, Araya-López C, Gajardo J, Merlet G, Cabezas R, Romero J, Quijada-Maldonado E (2022b) Diluent effects in the solvent extraction of rhenium (VII) with amine extractants in [Tf2N]-based ionic liquids: experimental and COSMO-RS analysis. Journal of Molecular Liquids 346: 117091. DOI: 10.1016/j.molliq.2021.117091.

Villarroel E, Merlet G, Olea F, Araya-López C, Brouwer T, Cabezas R, Romero J, Schuur B, Quijada-Maldonado E (2022c) Ionic liquid screening of Octachlorodibenzo-p-dioxin captured from water samples by σ-profile analysis for microextraction applications. Journal of Ionic Liquids 2(1): 100017. DOI: 10.1016/j.jil.2022.100017.

Zurob E, Rivas D, Olea F, Plaza A, Merlet G, Araya-López C, Romero J, Quijada-Maldonado E, Cabezas R (2022) Succinic acid recovery from a glycerol-based solution using phosphonium ionic liquids supported by COSMO-RS. Fluid Phase Equilibria 559: 113471. DOI: 10.1016/j.fluid.2022.113471.

Cabezas R, Duran S, Zurob E, Plaza A, Merlet G, Araya-Lopez C, Romero J, Quijada-Maldonado E (2021) Development of silicone-coated hydrophobic deep eutectic solvent-based membranes for pervaporation of biobutanol. Journal of Membrane Science 637: 119617. DOI: 10.1016/j.memsci.2021.119617.

Olea F, Merlet G, Araya-López C, Cabezas R, Villarroel E, Quijada-Maldonado E, Romero J (2021) Separation of vanillin by perstraction using hydrophobic ionic liquids as extractant phase: analysis of mass transfer and screening of ILs via COSMO-RS. Separation and Purification Technology 274: 119008. DOI: 10.1016/j.seppur.2021.119008.

Reinoso-Guerra E, Aristizabal J, Arce B, Zurob E, Dennett G, Fuentes R, Suescún AV, Cárdenas L, Rodrigues da Cunha TH, Cabezas R, García-Herrera C, Parra C (2021) Nanostructured Didymosphenia geminata-based membrane for efficient lead adsorption from aqueous solution. Journal of Environmental Chemical Engineering 9(4): 105269. DOI: 10.1016/j.jece.2021.105269.

Cabezas R, Prieto V, Plaza A, Merlet G, Quijada-Maldonado E, Torres A, Yáñez-S M, Romero J (2020) Extraction of vanillin from aqueous matrices by membrane-based supercritical fluid extraction: effect of operational conditions on its performance. Industrial & Engineering Chemistry Research 59(31): 14064-14074. DOI: 10.1021/acs.iecr.0c01272.

Plaza A., Cabezas R, Merlet G, Zurob E, Concha-Meyer A, Reyes A, Romero J (2020) Dehydrated cranberry juice powder obtained by osmotic distillation combined with freeze-drying: process intensification and energy reduction. Chemical Engineering Research & Design 160: 233-239. DOI: 10.1016/j.cherd.2020.05.003.

Plaza A, Tapia X, Yañez C, Vilches F, Candia O, Cabezas R, Romero J (2020) Obtaining hydroxytyrosol from olive mill waste using deep eutectic solvents and then supercritical CO2. Waste and Biomass Valorization 11(11): 6273-6284. DOI: 10.1007/s12649-019-00836-1.

Quijada-Maldonado E, Olea F, Sepúlveda R, Castillo J, Cabezas R, Merlet G, Romero J (2020) Possibilities and challenges for ionic liquids in hydrometallurgy. Separation and Purification Technology 251: 117289. DOI: 10.1016/j.seppur.2020.117289.

Quijada-Maldonado E., Allain A, Pérez B, Merlet G, Cabezas R, Tapia R, Romero J (2020) Selective liquid-liquid extraction of molybdenum (VI) and rhenium (VII) from a synthetic pregnant leach solution: comparison between extractants and diluents. Minerals Engineering 145: 106060. DOI: 10.1016/j.mineng.2019.106060.

Zurob E, Cabezas R, Villarroel E, Rosas N, Merlet G, Quijada-Maldonado E, Romero J, Plaza A (2020) Design of natural deep eutectic solvents for the ultrasound-assisted extraction of hydroxytyrosol from olive leaves supported by COSMO-RS. Separation and Purification Technology 248: 117054. DOI: 10.1016/j.seppur.2020.117054.

Cabezas R, Suazo K, Merlet G, Quijada-Maldonado E, Torres A, Romero J (2019) Performance of butanol separation from ABE mixtures by pervaporation using silicone-coated ionic liquid gel membranes. RSC Advances 9(15): 8546-8556. DOI: 10.1039/C8RA09630A.

Romero J, Zambra C, Merlet G, Cabezas R, Correa G, Salinas G, González J, Veliz F, Lemus-Mondaca R (2019) Liquid–liquid extraction of hydroxytyrosol, tyrosol, and oleuropein using ionic liquids. Separation Science and Technology 54(17): 2895-2906. DOI: 10.1080/01496395.2018.1555171.

Merlet G, Uribe F, Aravena C, Rodríguez M, Cabezas R, Quijada-Maldonado E, Romero J (2017) Separation of fermentation products from ABE mixtures by perstraction using hydrophobic ionic liquids as extractants. Journal of Membrane Science 537: 337-343. DOI: 10.1016/j.memsci.2017.05.045.

Cabezas R, Plaza A, Merlet G, Romero J (2015) Effect of fluid dynamic conditions on the recovery of ABE fermentation products by membrane-based dense gas extraction. Chemical Engineering and Processing-Process Intensification 95: 80-89. DOI: 10.1016/j.cep.2015.04.003.

Capítulos de libros
Romero J, Cabezas R, Araya-López C, Merlet G (2018) Membrane technology for catalytic processes in ionic liquids. En: Lozano P (Ed.) Sustainable Catalysis in Ionic Liquids. CRC Press.

Patentes

Sistema y Método para Concentración de Salmueras de Litio y Purificación de Agua. PCT/IB2023/057117

Mis líneas de investigación se centran en el estudio y diseño de nuevos procesos basados ​​en el uso de tecnologías de separación por membranas y su acoplamiento sinérgico con solventes verdes como fluidos supercríticos, líquidos iónicos y solventes eutécticos profundos.

Actualmente, trabajo en proyectos para el diseño y adaptación de estas tecnologías verdes, para ser aplicados a la obtención de biorecursos, como la producción de biocombustibles con la pervaporación del butanol desde el proceso de fermentación ABE, la producción de productos bloques o plataformas químicas con la obtención de ácido succínico mediante perstracción con membranas de líquido iónico, la separación y purificación de químicos de alto valor agregado como el hidroxitirosol mediante solventes eutécticos profundos naturales, así como también, el trabajo para la valorización de los residuos de la agroindustria, combinando también el tratamiento y funcionalización de biopolímeros para su aplicación en membranas.

Más información

Research Gate

Google Scholar (Google Académico)